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nano-scale aggregation state could be key mechanism of fluorescence response of chemosensor

posted Oct 25, 2017, 6:00 AM by Jun-Seok Lee   [ updated Apr 8, 2018, 11:55 PM ]
Precise molecular recognition mode between organic fluorophore-based chemosensor and target molecule has been presumed as the major origin of fluorescence turn-on phenomena. Recently, several research groups found nano-scale aggregation state is another key mechanism of fluorescence turn-on, even for the reknowned carbohydrate chemosensor. Our group envisioned neutral and hydrophobic dansyl fluorophore has great potential as chemosensor based on nano-aggregate state since they showed remarkable solvent dependent self-aggregation and fluorescence quenching. We prepared the first diversity-oriented fluorescence library of dansyl scaffold and found unique chemosensor for a steroid, progesterone. [link