Welcome
News
December, 2018
O-salicylaldehyde has been utilized for the N-term ser/thr selective ligation in organic condition, and we explored this chemistry in aqueous condition that led to discovery of N-term cys selectivity. (link)
June, 2018
Image-based host cell infection profiling using fluorescence superoxide probe perfectly discriminates 3 AI subtypes (H1N1, H5N9, H9N2). (link)
March, 2018
Live cell imaging of chloro-functionalized photo-affinity BODIPY probe reveals sub-cellular accumulations. This article was selected as cover feature. (link)
Jan, 2018
Cellular binding target of dansyl fluorophore containing vinylsulfone group was identified as 3-Phosphoglycerate dehydrogenase (PHGDH), a key enzyme in the biosynthesis of serine. (link)
Oct, 2017
Aggregation property of organic fluorophore can be a key for biomolecule sensing. We demonstrated bulk aggregation based fluorescence turn-on sensor for progesterone using Dansyl scaffold. It was selected as Hot Paper from Angew. Chem. (link)
Aug, 2017
Comprehensive evaluation of bio-orthogonal photo-crosslinker for bio-active small molecule was studied (BRD4 inhibitor case study). (link)
May, 2016
First 48 membered dansyl library (DS) synthesis and their photo-physical properties were reported. (link)
July, 2015
Dr. Murale awarded Korea Research Fellowship program. Congratulations!! (link1, link2)
April, 2015
The first photo-affinity BODIPY scaffold was published in Chem. Comm. (link)
April, 2015
Transcriptome expression assisted non-directed proteomic profiling (TEAnDPP) strategy demonstrated identification of host cell response factors. (link)
April, 2015
Unbiased fluorophore tagging together with competitive chemical proteomic profiling reveals host cell cycle regulator from Salmonella. (link)
March, 2014
Novel method to distinguish pathogenic bacteria using proteome reactivity profile was published in Chem. Comm. (link)
February, 2014
Synthetic chemist point of view regarding activity-based protein profiling (ABPP) was published in BMB Reports. (link)
March, 2012
The first fluorescence image-based phenomic profiling study was published in PLOS ONE. (link)
December, 2010
The first BODIPY library paper was selected as JACS Select collection focused on Supramolecular and Chemical Cascade Approaches to Molecular Sensing ( J. Am. Chem. Soc. 2009, 131, 10077-10082).
Positions
Post-doctoral position: we are seeking for highly motivated applicant who has doctoral degree with experience on biochemistry, chemical biology, or molecular biology. Please submit application with CV and email address of references to Dr. Lee (junseoklee at chembiol.re.kr).
Graduate/Undergraduate/high school student: Highly motivated students are always welcome. Please send an email to Dr. Lee with a transcript and a letter describing yourself and academic interest.