Publications

Rational Design of Activatable Near-Infrared Fluorogenic Platform for In Vivo Orthotopic Tumor Imaging and Resection

• Wu, X.; Deng, Y. D.; Wang, R.; Kim, H.; Kim, G.; Xu, Y.; Hong, K. T.; Lee, J. S.; Hu, J. J.; Liang, G.; Yoon, J.

• Angew. Chem. Int. Ed., 2024, in press.

Sensing and imaging approaches for cyclooxygenase enzyme

• Cheekatla, S. R.; Murale, D. P.*; Gopala, L.; Lee, J. S.*

• ChemMedChem, 2024, in press.

Differential sensing approach as a pattern-based discrimination for biological samples

• Jo, S. B.; Lee, J. H.; Lee, J.; Oh, M. M.; Lee, J. S.*

• Chem. Eur. J. 2024, 30(60), e202402871. 

• Selected as a Cover Feature

Tuning singlet oxygen generation with caged organic photosensitizers

• Nestoros, E.; Moliner, F.; Nadal-Bufi, F.; Seah, D.; Ortega-Liebana, M. C.; Benson, S.; Cheng, Z.; Adam, C.; Maierhofer, L.; Kozoriz, K.; Lee, J. S.; Unciti-Broceta, A.; Vendrell, M.

• Nat. Commun. 2024, 15, 7689.

Disaggregation-Activated pan-COX Imaging Agents for Human Soft Tissue Sarcoma

• Hong, K. T.; Park S. B.; Murale, D. P.; Lee, J. H.; Hwang, J.; Jang, W. Y.*; Lee, J. S.*

• Angew. Chem. Int. Ed., 2024, 63 (24), e202405525

• Hot Topic: Tumors and Cancer

• Selected as an Inside Cover Feature

NeuM: A Neuron-Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin-Mediated Endocytosis in Primary Neurons.

• Sung, Y.; Gotina, L.; Kim, K. H.; Lee, J. Y.; Shin S.; Aziz, H.; Kang, D. M.; Liu, X.; Hong, N. K.; Lee, H. G.; Lee, J. S.; Ku, H.; Jeong, C.; Pae, A. N.; Lim, S.; Chang, Y. T.; Kim, Y. K.

• Angew. Chem. Int. Ed., 2024, 63 (3), e202312942.

Fluorescent Phenotyping of Blood Cells Using a Differential Sensing Strategy: Differentiating Physiological Aging Stages and Neuro-degenerative Disease Drugs

• Lee, J. H.; Yoon, H. Y.; Lee, H. J.; Kang, D. M.; Bak, Y.; Biazruchka, I.; Lim, S.; Kim, S.*; Kim, Y. K.*; Kim, D. H.*; Lee, J. S.*

• Chem. Eur. J. 2024, 30, e202302916.

Reassessing the genetic lineage tracing of lingual Lgr5+/6+-expressing cells in vivo.

•  Kim, H. J.; Seo, D. W.; Shim, J.; Lee, J. S.; Choi. S. H.; Kim, D. H.; Moon S. J.; Jung, H. S.; Jeong, Y. T.

• Anim. Cells Syst. 2024, 28, 353-366

Recent advances in enzyme-activated NIR fluorescent probes for biological applications

• Jeong, H.; Wu, X.*; Lee, J. S.*; Yoon, J.*

• Trends Anal. Chem., 2023, 168, 117335.

Reaction-based Electrochemiluminescent Chemodosimeters for Reactive Species Detection in Biomedical Applications

• Cheektala, S. R.; Yoon, H. Y.; Choi, S. H.; Lee, J. S.*

• ChemElectroChem, 2023, 10, e202300259.

Inhibition of adipose tissue angiogenesis prevents rebound weight gain after caloric restriction in mice fed a high-fat diet

• Lee, H. J.; Jun, B. Y.; Park, M. R.; Kim, N. H.; Seo, K. S.; Jeong, Y. T.; Wada, T.; Lee, J. S.; Choi, S. H.; Kim, D. H.

• Life Sci. 2023, 332, 122101.

Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells

• Mersal, K.; Abdel-Maksoud M.; Ammar, U.; Ali, E.; Zaraei, S. O.; Haque, M. M.; Das, T.; Lee, J. S.; Kim, E.; Lee, K. H.; Oh, C.

• Eur. J. Med. Chem. 2023, 261, 115779.

생명현상과 합성화학: 관찰과 개입

• 과총 2023년 3월호: 특집-<합성화학의 세계>

Multifunctional Photo-Cross-linking Probes: From Target Protein Searching to Imaging Applications

• Kozoriz, K; Shkel, O; Hong, K. T.; Kim, D. H.; Kim, Y. K.; Lee, J. S.*

• Acc. Chem. Res. 2023, 56, 1, 25-36.

• Selected as an Inside Cover Feature

Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice

• Lim, S.; Shin, S.; Lee, H. E.; Song, J. Y.; Sung, Y.; Lee, G. H.; Yu, B. Y.; Aziz, H.; Lukianenko, N.; Kim, K. H.; Jeong, H.; Lim, S. M.; Lee, J. S.; Pae, A. N.; Kim, Y. K.

• Exp. Mol. Med. 2023,  55, 612-627. (Research Square, 2021, pre-print.)

Dual-modal iridium-based self-immolative chemosensors for differential responses against reactive oxygen species and their applications to detect diabetes

• Yoon, H. Y.; Bak, Y.; Park, S. B.; Cheektala, S. R.; Shin, K. H.; Kim, S.*; Lee, J. S.*

• Adv. Mater. Interfaces, 2023, 2202408.

Cytarabine induces cachexia with lipid malabsorption via lacteal junction zippering in murine small intestine

• Park, M. R.; Lee, H. J.; Jang, H. M.; Kim, N. H.; Lee, J. S.; Jeong, Y. T.; Kim, I.; Choi, S. H.; Seo, K. S.; Kim, D. H.

• J. Lipid Res., 2023, 64(6) 100387. (Authorea, 2022, pre-print) 

Metformin acts as a dual glucose regulator in mouse brain

• Jin, B. Y.; Kim, H. J.; Oh, M. J.; Ha, N. H.; Jeong, Y. T. ; Choi, S. H.; Lee, J. S.; Kim, N. H.; Kim, D. H.

• Front. Pharmacol., 2023, 14:1108660.

Orthogonally-Tunable and ER-Targeting Fluorophores Detect Avian Influenza Virus Early Infection

• Kang, T.; Haque, M. M.; Lee, B.; Hong, K. T.; Hong, S. C.; Kim, Y.; Lee, J.; Lee, J. S.*; Lee, D.* 

• Nat. Commun. 2022, 13. 5841.

• Highlighted in SynFacts

Temporal control of protein labeling by photo-caged benzaldehyde motif and discovery of host cell factors of avian influenza virus infection

• Asiimwe, N.; Lee, J. H.; Hong, K. T.; Murale, D. P.; Haque, M. M.; Kim, D. H.; Lee, J. S.*

• Chem. Comm. 2022, 58, 9345-9348.

Development of tricyanofuran-based activity probes for sulfatase assay in live cells

• Yoon, H. Y.; Lee, J. H.; Park, S. B.; Choi, S. H.; Lee, J. S.*; Hong, J. I.*

• Dyes Pigm. 2022, 205, 110517.

Discovery of penta-peptides inhibiting activity of formylglycine generating enzyme and its potential antibacterial effect against Mycobacterium tuberculosis

• Asiimwe, N.; Mazid, M. F. A.; Jeong, Y. T.; Lee, J.; Lee, J. S.*

• RSC Adv. 2022, 12, 18884-18888.

Chemical Probes and Activity-based Protein Profiling for Cancer Research

• Mazid, M. F. A.; Park, S. B.; Cheekatla S. R.; Murale, D. P.; Shin, K. H.; Lee, J. S.*

• Int. J. Mol. Sci. 2022, 23(11), 5936. 

Organelle-specific Fluorescent Phenomics and Transcriptomic Profiling to Evaluate Cellular Response to Tris(1,3 dichloro 2 propyl)phosphate

• Haque, M. M.; Taras, V.; Lee, J. S.*

• Sci. Rep., 2022, 12, 4660.

Dabigatran acylglucuronide, the major metabolite of dabigatran, shows a weaker anticoagulant effect than dabigatran

• Kim, J. M.; Noh, J. H.; Park, J. W.; Chung, H.; Kim, K. A.; Park, S. B.; Lee, J. S.*; Park, J. Y.*

• Pharmaceutics, 2022, 14(2), 257.

Bioinformatic expansion of borosins uncovers trans-acting peptide backbone N-methyltransferases in bacteria

• Cho, H.; Lee, H.; Hong, K.; Chung, H.; Song, I.; Lee, J. S.; Kim, S.

• Biochemistry, 2022, 3, 183-194.

Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAFV600E/p38α kinase inhibitory activity: Synthesis, in vitro assays and in silico study

• Ali, E. M. H.; Mersal, K. I.; Ammar, U. M.; Zaraei, S. O.; Abdel-Maksoud, M. S.; El-Gamal M. I.; Haque, M. H.; Das, T.; Kim, E.; Lee, J. S.; Lee, Lee, K. H.; Kim, H. K.; Oh, C.

• Eur. J. Pharm. Sci., 2022, 171, 106115.

Recent trends in molecular aggregates: an exploration of biomedicine

• Heo, J.; Murale, D. P.; Yoon, H. Y.; Arun, Y.; Choi, S.; Kim, E.*; Lee, J. S.*; Kim, S.*

• Aggregate, 2022, 3(2), e159.

Proximity Labeling Techniques: a Multi-Omics Toolbox

• Shkel, O.; Kharkivska, Y.; Kim, Y. K.*; Lee, J. S.* 

• Chem. Asian J. 2022, 17(2), e202101240. 

• Selected as a Front Cover

Recent Advances in Protein Modifications Targeting N-terminal Cysteine

• Asiimwe, N.; Mazid, M. F. A.; Murale, D. P.; Kim, Y. K.; Lee, J. S.*

• Pept. Sci. 2022, 114(3), e24235.

• Selected as a Front Cover

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

• de Moliner, F.; Biazruchka, I.; Konsewicz, K.; Benson, S.; Singh, S.; Lee, J. S.*; Vendrell, M.*

• Front. Chem. Sci. Eng., 2022, 16(1), 128-135.

Development of a bifunctional BODIPY probe for mitochondria imaging and in situ photo-crosslinking in live cell

• Murale, D. P.; Haque, M. M.; Hong, S. C.; Jang, S. Y.; Lee, J. H.; An, S. J.; Lee, J. S.*

• Dyes Pigm. 2021, 196, 109830.

Photoactivatable Metabolic Warheads Enable Precise and Safe Ablation of Target Cells in Vivo

• Benson, S.; Moliner, F.; Fernandez, A.; Kuru, E.; Asiimwe, N.; Lee, J. S.; Hamilton L.; Sieger, D.; Bravo, I. R.; Elliot, A.; Feng, Y.; Vendrell, M. 

• Nat. Commun. 2021, 12, 2369.  [ChemRxiv, 2021, pre-print.]

Application of Fluorescent turn-on Aptamers in RNA Studies 

• Mazid, M. F. A.; Shkel, O.; Kharkivska, Y.; Lee, J. S.* 

• Mol. Omics, 2021, 17, 483-491. 

A pyridinyl-pyrazole BODIPY as lipid droplets probe

• Murale, D. P.; Haque, M. M.; Hong, K. T.; Lee, J. S.*

• Bull. Korean Chem. Soc. 2021, 42, 111-114. (invited article)

Kidney-Targeted Cytosolic Delivery of siRNA Using a Small-Sized Mirror DNA Tetrahedron for Enhanced Potency

• Tai, H. B. D.; Hong, K. T.; Voitsitskyi, T.; Lee, J. S.; Mao, C.; Ahn, D. R.

• ACS Cent. Sci. 2020, 6, 12, 2250–2258.

다양한 타겟 분석을 위한 화학센서 연구 동향

• Yoon, H. Y.; Hong, K. T.; An, S. J.; Lee, J. S.*

• KIC News, 2020, 23(3), 42-55.

Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis

• Haque, M. M.; Murale, D. P.; Lee, J. S.*

• Int. J. Mol. Sci. 2020.  21(23), 8962.

2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments

• El-Damasy, A. K.; Haque, M. M.; Park, J. W.; Shin, S. C.; Lee, J. S.; Kim E. E.; Keum, G. 

• Eur. J. Med. Chem. 2020, 208, 112756. 

Activity-based probes for the high temperature requirement A serine proteases

• Nam, H. Y.; Song, D.; Eo, J.; Choi, N. E.; Hong, J. A.; Hong, K. T.; Lee, J. S.; Seo J.; Lee, J.

• ACS Chem. Biol. 2020, 15, 2346-2354. 

Targeted Degradation of Transcription Co-activator SRC-1 through the N-Degron Pathway

• Lee, Y.; Heo, J.; Jeong, H.; Hong, K. T.; Kwon, D. H.; Shin, M. H.; Oh, M.; Sable, G. A.; Ahn, G. O; Lee, J. S.*; Song, H. K. *; Lim, H. S.*

• Angew. Chem. Int. Ed. 2020, 59,17548-17555.

Label-free proteome profiling as a quantitative target identification technique for bioactive small molecules

• Hong, K. T.; Lee, J. S.*

• Biochemistry,  2020, 59, 3, 213-215

Investigation of memory-enhancing botanical mixture and their isolated compounds for inhibition of amyloid-β and tau aggregation 

• Baek, S.; Park, S.; Shin, J.; Lee, J. S.; Kim, H. Y.; Han, G.; Kim, Y. 

• Appl. Biol. Chem. 2020 63:22. 

Affinity-based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors

• Ma, N.; Zhang, Z. M.; Lee, J. S.; Cheng, K.; Lin, L.; Zhang, D. M.; Hao, P.; Ding, K.; Ye, W. C.; Li, Z.

• ACS Chem. Biol. 2019, 14, 12, 2546-2552

A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2

• Kim, J. J.; Lee, Y. A.; Su. D.; Lee, J.; Park, S. J.; Kim, B.; Lee, J. H. J.; Liu, X.; Kim, S. S.; Bae, M. A.; Lee, J. S.; Hong, S. C.; Wang, L.; Samanta, A.; Kwon, H. Y.; Choi, S. Y.; Kim, J. Y.; Yu, Y. H.; Ha, H. H.; Wang, Z.; Tam, W. L.; Lim, B.; Kang, N. Y.; Chang, Y. T.

• J. Am. Chem. Soc. 2019, 141,14673-14686. 

Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

• Jeong, H.; Shin, S.; Lee, J. S.; Lee, S. H.; Baik J. H.; Lim, S.; Kim, Y. K. 

• Int. J. Mol. Sci. 2019, 20(17), 4283 

Crosstalk between Oxidative Stress and Tauopathy. 

• Haque, M. M.; Murale, D. P.; Kim, Y. K.*; Lee, J. S.* 

• Int. J. Mol. Sci. 2019, 20(8), 1959 

Expanding the “minimalist” small molecule tagging approach to different bioactive compounds. 

• Lang, W.; Yuan, C.; Zhu, B.; Pan, S.; Liu, J.; Luo, J.; Nie, S.; Zhu, Q.; Lee, J. S.; Ge, J. 

• Org. Biomol. Chem. 2019, 17, 3010-3017. 

Recent developments in metal catalyzed bio-orthogonal reactions for biomolecule tagging. 

• Jang, S. Y.; Murale, D. P.; Kim, A. D.; Lee, J. S.* 

• ChemBioChem, 2019, 20, 1498-1507. 

Differentiation of Selectively Labeled Peptides using Solid-State Nanopores. 

• Yu, J.; Hong, S. C.; Wu, S.; Kim, H. M.; Lee, C.; Lee, J. S.; Lee, J. E.; Kim, K. B. 

• Nanoscale, 2019, 11, 2510-2520.

Live-Cell Imaging and Profiling of c-Jun N-Terminal Kinases with Covalent Inhibitor-Derived Probes. 

• Qian L.; Pan, S.; Lee, J. S.; Ge, J.; Yao, S. Q. 

• Chem. Comm. 2019, 55, 1092-1095. 

Reinvestigation of O-salicylaldehyde ester functional group in aqueous buffer and discovery of a coumarin scaffold probe for selective N-terminal cysteine labeling. 

• Murale, D. P.; Hong, S. C.; Jang, S. Y.; Lee, J. S.* 

• ChemBioChem 2018, 19, 2545-2549. 

• Selected as a ChemBioTalent

Discrimination of Avian Influenza Virus using Host-cell Infection Fingerprinting by Sulfinate-based Fluorescence Superoxide Probe. 

• Hong, S. C.; Murale, D. P.; Jang, S. Y.; Haque, M. M.; Seo, M.; Lee, S.; Woo, D. H.; Kwon,J.; Song, C. S.; Kim, Y. K.; Lee, J. S.*  

• Angew. Chem. Int. Ed., 2018, 57, 9716-9721.

Chloro-functionalized photo-crosslinking BODIPY for glutathione sensing and sub-cellular trafficking. 

• Murale, D. P.; Hong, S. C.; Haque, M. M.; Lee, J. S.* 

• ChemBioChem 2018, 19, 1001-1005.  

• Selected as a Cover Feature

Mono-allyloxylated Cucurbit[7]uril Acts as an Unconventional Amphiphile to Form Light-responsive Vesicles. 

• Park, K. M.; Baek, K.; Ko, Y. H.; Shrinidhi, A.; Murray J.; Jang, W. H.; Kim, K. H.; Lee, J. S.; Yoo, J.; Kim, S.; Kim.K. 

• Angew. Chem. Int. Ed., 2018, 57, 3132 - 3136.

Identification of Tumor Initiating Cells by a Small Molecule Fluorescent Probe by Using Vimentin as a Biomarker. 

• Lee, Y. A.; Kim, J. J.; Lee, J.; Sahu, S.; Kwon, H. Y.; Park, S. J.; Lee, J. H.; Jang, S. Y.; Lee, J. S.; Wang, Z.; Tam, W. L.; Lim, B.; Kang, N. Y.; Chang, Y. T.  

• Angew. Chem. Int. Ed., 2018, 57, 2851-2854.

A vinyl sulfone-based fluorogenic probe capable of selective labeling of PHGDH in live mammalian cells. 

• Pan, S.; Jang, S. Y.; Liew, S. S.; Fu, J.; Wang, D.; Lee, J. S.*; Yao, S. Q.* 

• Angew. Chem. Int. Ed., 2018, 57, 579-583.

A novel computational method for biomedical binary data analysis: development of a thyroid disease index using a brute-force search with MLR analysis. 

• Lee, J. K.; Han, W. S.; Lee, J. S.; Yoon, C. N. 

• Bull. Korean Chem. Soc., 2017, 38(12), 1392-1397.

A chemoselective cleavable fluorescence turn-on linker for proteomic studies. 

• Liew, S. S.; Du, S.; Ge, J.; Pan, S.; Jang, S.; Lee, J. S.*; Yao, S. Q.* 

• Chem. Comm. 2017, 53, 13332-13335.

Tetrazole-based probes enable integration of phenotypic screening with target identification and distinct profiling of a cancer biomarker. 

• Chen, K.; Lee, J. S.; Hao, P.; Yao, S. Q.; Ding, K.; Li, Z. 

• Angew. Chem. Int. Ed., 2017, 56,15044-15048.

Bulk aggregation based fluorescence turn-on sensors for selective detection of progesterone in aqueous solution. 

• Hong, S. C.; Murale, D. P.; Lee, M.; Lee, S. M.; Park, J. S.; Lee, J. S.* 

• Angew. Chem. Int. Ed., 2017, 56, 14642 –14647.  

• Selected as Hot Paper  

• Author interview from BRIC

A suite of "minimalist" photo-crosslinkers for live-cell imaging and chemical proteomics: Case study with BRD4 inhibitors. 

• Pan, S.; Jang, S. Y.; Wang, D.; Liew S. S.; Li, Z.; Lee, J. S.*; Yao, S. Q.*  

• Angew. Chem. Int. Ed., 2017, 56, 11816-11821.

Nano metamaterials for ultrasensitive Terahertz biosensing. 

• Lee, D. K.; Kang, J. H.; Kwon J.; Lee, J. S.; Lee, S.; Woo, D. H.; Kim, J. H.; Song, C. S.; Seo, M. 

• Sci. Rep. 2017, 7, 8146.

Cell type selective imaging and profiling of newly synthesized proteomes by using puromycin analogues. 

• Du, S.; Wang, D.; Lee, J. S.; Peng, B.; Ge, J.; Yao, S. Q. 

• Chem. Comm. 2017, 53, 8443-8446.

Photo-affinity labelling (PAL) in chemical proteomics: A handy tool to investigate protein-protein interactions (PPIs)  

• Murale, D. P.; Hong, S. C.; Haque, M. M.; Lee, J. S.* 

• Proteome Sci. 2017, 15:14.

Global mapping of protein-lipid Interactions by using modified choline-containing phospholipids metabolically synthesized in live cells. 

• Wang, D.; Du, S.; Cazenave-Gassiot, A.; Ge, J.; Lee, J. S.; Wenk, M. R.; Yao, S. Q.  

• Angew. Chem. Int. Ed., 2017, 56, 5829-5833.

β1,6-GlcNAc Linkage to the Core Glycan on TIMP-1 Affects Its Gelatinase Inhibitory Activities: Aberrantly Glycosylated TIMP-1-MMP2 Complex Modeling Shows Weaker Interaction Compared to Bi-antennary Glycosylated TIMP-1. 

• Lee, J. K.; Han, W. S.; Lee, J. S.; Kim, Y. S.; Ko, J. H.; Yoo, J. S.; Yoon, C. N.  

• Bull. Korean Chem. Soc., 2017, 38(3), 384-388.

Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells. 

• Lim, S.; Haque, M. M.; Su, D.; Kim, D.; Lee, J. S.; Chang, Y. T.; Kim, Y. K. 

• Chem. Comm. 2017, 53, 1607-1610.

In situ proteome profiling and bioimaging applications of small molecule affinity-based probes derived from DOT1L inhibitors. 

• Zhu, B.; Zhang, H.; Pan, S.; Wang, C.; Ge, J.; Lee, J. S.; Yao, S. Q. 

• Chem, Eur. J. 2016, 22, 7824-7836.

Tetrazole photoclick chemistry: Reinvestigating its suitability as a bioorthogonal reaction and potential applications. 

• Li, Z.; Qian, L.; Li, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J. S.; Yao, S. Q.  

• Angew. Chem. Int. Ed.,2016, 55, 2002-2006.

Combinatorial dansyl library and its applications to pH-responsive probes. 

• Hong, S. C.; Murale, D. P.; Lee, J. S.* 

• Comb. Chem. High T. Scr. 2016, 19(5), 347-352.

저분자 프로브를 이용한 분자영상법 

• Chemworld (화학세계), 2016, 56, 1, p11

Highly sensitive and selective sugar detection by terahertz nano-antennas. 

• Lee, D. K.; Kang, J. H.; Lee, J. S.; Kim, H. S.; Kim, C.; Kim, J. H.; Lee, T.; Son, J. H.; Park, Q. H.; Seo, M. 

• Sci. Rep. 2015, 5, 15459. [arXiv:1506.08363]

Identification of disulfide cross-linked tau dimer responsible for tau propagation. 

• Kim, D. H.; Lim, S.; Haque, M.; Ryoo, N.; Hong, H. S.; Rhim, H.; Lee, D. E.; Chang, Y. T.; Lee, J. S.; Cheong, E.; Kim, D. J.; Kim, Y. K. 

• Sci. Rep. 2015, 5, 15231.

A small molecule probe capable of selective profiling and imaging of Monoamine Oxidase B activities in Parkinson's Disease models. 

• Li, l.; Zhang, C. W.; Ge, J.; Qian L.; Chai, B. H.; Zhu, Q. Z.; Lee, J. S.;Lim, K. L.; Yao, S. Q. 

• Angew. Chem. Int. Ed., 2015, 54, 10821-10825.

Rational design of a photo-crosslinking BODIPY for in situ protein labeling. 

• Murale, D. P.; Hong, S. C.; Yun, J.; Yoon, C. N.; Lee, J. S.* 

• Chem. Comm., 2015, 51, 6643-6646. 

Chemical proteomic identification of T-plastin as novel host cell response factor in HCV infection. 

• Yoo, Y. H.; Yun, J.; Yoon, C. N.; Lee, J. S.* 

• Sci. Rep., 2015, 5, 9773. [Go to GEO dataset]

Unbiased proteomic profiling strategy for discovery of bacterial effector proteins reveals that Salmonella protein PheA is a host cell cycle regulator. 

• Na, H.; Yoo, Y. H.; Yoon, C. N.; Lee, J. S.* 

• Chem. Biol., 2015, 22, 453-459.  

• Highlighted at "Chemical proteomics of host-pathogen interaction", Chem. Biol., 22, 434

A small molecule protein-protein interaction inhibitor of PARP1 that targets its BRCT domain. 

• Na, Z.; Peng, B.; Ng, S.; Pan, S.; Lee, J. S.; Shen, H. M.; Yao, S. Q.  

• Angew. Chem. Int. Ed., 2015, 54, 2515-2519.

Diversity oriented approach for chemical biology. 

• Lee, J. S.; Lee, J.W.; Kang, N.; Ha, H.H.; Chang, Y. T. 

• Chem. Rec., 2015, 15, 495-510.

Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses. 

• Park, S.J.; Yeo, H.; Kang, N.Y.; Kim, H.; Lin, J.; Ha, H.H.; Vendrell, M.; Lee, J. S.; Chandran, Y.; Lee, D.Y.; Yun, S.W.; Chang, Y. T. 

• Stem Cell Res., 2014, 12(3), 730-741. 

Proteome reactivity profiling for the discrimination of pathogenic bacteria. 

• Lee, J. S.*; Yoo, Y.H.; Kang, J.H.; Han, W.S.; Lee, J.K.; Yoon, C.N. 

• Chem. Comm., 2014, 50(33), 4347-4350.

Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development. 

• Yun, S.W.; Kang, N.Y.; Park, S.J.; Ha, H.H.; Kim, Y.K.; Lee, J. S.; Chang, Y.T. 

• Acc. Chem. Res., 2014, 47, 1227-1286.

Small-molecule probes elucidate global enzyme activity in a proteomic context. 

• Lee, J. S.*; Yoo, Y.H.; Yoon, C.N. 

• BMB Rep., 2014, 47(3), 149-157.

Focused fluorescent probe library for metal cations and biological anions. 

• Rhee, H.W.; Lee, S.W.; Lee, J. S.; Chang, Y. T.; Hong, J. I. 

• ACS Combi. Sci., 2013, 15, 483-490. 

Study of thiazoline derivatives for the design of optimal fungicidal compounds using multiple linear regression (MLR). 

• Han, W. S.; Lee, J. K.; Lee, J. S.; Hahn H.; Yoon, C. N. 

• Bull. Korean Chem. Soc., 2012, 33(5), 1703-1706.

Identification of cancer cell-line origins using fluorescence image-based phenomic screening. 

• Lee, J. S.; Kim, Y. K.; Kim, H.; Hajar S.; Tan, Y. L.; Kang, N. Y.; Ng, S. H.; Yoon, C. N.; Chang, Y. T.  

• PLOS ONE, 2012, 7 (2):e32096e 

Diversity-oriented optical imaging probe development. 

• Lee, J. S.; Vendrell, M.; Chang, Y. T.  

• Curr. Opin. Chem. Biol., 2011, 15, 760-767. 

Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor. 

• Vendrell, M.; Krishna, G.G.; Ghosh K. K.; Zhai, D.; Lee, J. S.; Zhu, Q.;Yau, Y.H.; Shochat S.G.; Kim, H.; Chung, J.; Chang, Y. T.  

• Chem. Comm., 2011, 47, 8424-8426. 

Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain. 

• Kim, Y.K.; Lee, J. K.; Lee, J. S.; Yoon, C.N.; Chang, Y. T. 

• Mol. Biosys.,2011, 7, 2375-2378. 

A colorimetric pH indicator and boronic acid ensemble array for quantitative sugar analysis. 

• Ghosh, K.K.; Yap, E.; Kim, H.; Lee, J. S.; Chang, Y. T. 

• Chem. Comm., 2011, 47, 4001-4003. 

The binding of fluorophores to proteins depends on the cellular environment. 

• Kim, Y.K.; Lee, J. S.; Bi, X.; Ha, H.H.; Ng, S. H.; Ahn, Y.H.; Lee, J.J.; Wagner, B.K.; Clemons, P.A.; Chang, Y. T. 

• Angew. Chem. Int. Ed., 2011, 50, 2761-2763. 

Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library. 

• Lee, J. S.; Kim, H. K.; Feng, S.; Vendrell, M; Chang, Y. T. 

• Chem. Comm., 2011, 47, 2339-2341. 

Fluorescence response profiling for small molecule sensors utilizing the green fluorescent protein chromophore and its derivatives. 

• Lee, J. S.; Baldridge, A.; Feng, S.; Yang, S.; Kim, Y.K.; Tolbert, L.; Chang, Y. T.  

• ACS Combi. Sci., 2011, 13, 32-38. 

Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques. 

• Hong, M. C.; Kim, Y. K.; Choi, J.Y.; Yang, S.Q.; Rhee, H.; Ryu, Y.H.; Choi, T.H.; Cheon, G. J.; An, G. I.; Kim, H.Y.; Kim, Y.; Kim, D.J.; Lee, J. S.; Chang, Y.T.; Lee, K.C. 

• Bioorg. Med. Chem. 2010, 18, 7724-7730. 

Quantitative structure-fluorescence property relationship analysis of a large BODIPY library. 

• Schuller A.; Goh G.B.; Lee, J. S.; Chang, Y. T. 

• Mol. Inf., 2010, 29, 717-729. 

A fluorescent rosamine compound selectively stains pluripotent stem cells. 

• Im, C.N.; Kang, N.Y.; Ha, H. H.; Bi, X.; Lee, J.J.; Park, S.J.; Lee, S.Y.; Vendrell, M.; Kim, Y.K.; Lee, J. S.; Li, J.; Ahn, Y.H.; Feng, B.; Ng, H.H.; Yun, S. W.; Chang, Y. T. 

• Angew. Chem. Int. Ed., 2010, 49, 7497-7500.  

• Highlighted at "Fluorescence method detects stem cells", C&En News, 2010 (September 20), 88 (38), p 25

Diversity-oriented fluorescence library approaches for probe discovery and development. 

• Vendrell, M.; Lee, J. S.; Chang, Y. T.  

• Curr. Opin. Chem. Biol., 2010, 14 (3), 383-389. [Video Abstract]

Isozyme-specific fluorescent inhibitor of glutathione S-transferase omega 1. 

• Son, J; Lee, J. J.; Lee, J. S.; Schuller, A.; Chang, Y. T. 

• ACS Chem. Biol. 2010, 5 (5), 449-453. 

Control of muscle differentiation by a mitochondria-targeted fluorophore. 

• Kim, Y. K.; Ha, H. H.; Lee, J. S.; Bi, X. Z.; Ahn, Y. H.; Hajar, S.; Lee, J. J.; Chang, Y. T. 

• J. Am. Chem. Soc., 2010, 132, 576 - 579. 

Colorimetric sensor array for qualitative water analysis. 

• Chan, S. A.; Lee, J. S.; Chang, Y. T. 

• Aust. J. Chem. 2009, 62, 1040-1046. 

Synthesis of a bodipy library and its application to the development of live cell glucagon imaging probe. 

• Lee, J. S.; Kang, N.Y.; Kim, Y. K.; Samanta, A.; Feng, S.; Kim, H.K.; Vendrell, M.; Park, J.H.; Chang, Y. T. 

• J. Am. Chem. Soc. 2009, 131, 10077-10082.  

• Highlighted at JACS Select issue 10: Supramolecular and Chemical Cascade Approaches to Molecular Sensing 

• Recommended in F1000

Diversity-oriented fluorescence library approach for the discovery of sensors and probes. 

• Lee, J. S.; Kim,Y.K.; Vendrell, M.; Chang, Y. T. 

• Mol. BioSyst., 2009, 5, 411-421. 

A selective human serum albumin sensor from screening of fluorescent rosamine library. 

• Ahn, Y.H.; Lee, J. S.; Chang, Y. T. 

• J. Comb. Chem. 2008, 10, 376-380. 

Counterion free colorimetric metal cation sensor array. 

• Lee, J. S.; Lee, J.W.; Chang, Y. T. 

• J. Comb. Chem. 2007, 9, 926-928. 

Understanding the activity of small molecules in the genomics context. 

• Lee, J. S.; Chang, Y. T. 

• Angew. Chem. Int. Ed., 2007, 46, 3616-3618. 

Combinatorial rosamine library and application to in vivo glutathione probe. 

• Ahn, Y.H.; Lee, J. S.; Chang, Y. T. 

• J. Am. Chem. Soc. 2007, 129, 4510-4511. 

Colorimetric identification of carbohydrates by a pH indicator/ pH change inducer ensemble. 

• Lee, J. W.; Lee, J. S.; Chang, Y. T. 

• Angew. Chem. Int. Ed., 2006,45, 6485-6487.  

• Highlighted at "Discriminating between carbohydrates", C&En News, 2006 (September 25), 84 (39), p 90

Visual artificial tongue for quantitative metal cation analysis by an off-the-shelf dye array. 

• Lee, J.W.; Lee, J. S.; Kang, M.; Su, A. I.; Chang, Y. T. 

• Chem. Eur. J. 2006, 12, 5691-5696. 

Solid-phase synthesis of styryl dyes and their application as amyloid sensors. 

• Li, Q.; Lee, J. S.; Ha, C.; Park, C.B.; Yang G.; Gan, W. B.; Chang, Y. T. 

• Angew. Chem. Int. Ed., 2004, 43, 6331-6335.