Chemical Proteomics Tool
We are interested in the identification of protein interaction partners of small molecules. To visualize the drug-like small molecule's cellular localizations, our group developed fluorescent photo-crosslinking scaffold. This fluorescent photo-crosslinker can be attached into any functional ligands to explore cellular localization study as well as cellular interactome.
Fluorescent organic dyes have received considerable attentions for biological imaging. There are two types of fluorescence agents for bio-imaging. First, bright fluorophores have high potential as an imaging tag for endogenous biomolecules, including protein and metabolites. In such classes of compounds, the fluorophores play roles as a signal generator to tracking the biomolecules. On the other hands, a fluorescent molecule that changes its intensity or color has a high potential as a biosensor. Our group interested in a development of novel fluorescence chemosensors for biomolecules and study the mode of actions.
Chemical proteomics tool and chemosensors were applied in pathogenic bacteria or virus infection model to investigate the mechanism of host-pathogen interactions. We are currently particularly interested in avian influenza virus infection.